Maria E. Cruz
PhD (1985) in Biochemistry (Biochemistry/Biophysics), Universidade Nova de Lisboa
Seniour Researcher, with Habilitation, retired from Faculdade de Farmácia, Universidade de Lisboa
Faculdade de Farmácia, Universidade de Lisboa — Av. Prof. Gama Pinto, 1649-003 Lisboa, Portugal
Exploring a nanotecnological platform to modulate bioactive agents transport to specific sites. Focus is put in the treatment of Infectious diseases due to intracellular microorganisms, by means of optimizing the delivery of conventional drugs and of new agents obtained by interdisciplinary collaborations. To reach this goal appropriate lipid drug delivery systems, namely Liposomes, are used to produce nanoformulations of bioactive agents, followed by in vitro and in vivo assays.
Lopes R, Pereira J, Esteves MA, Gaspar MM, Carvalheiro M, Eleutério CV, Gonçalves L, Jiménez-Ruiz A, Almeida AJ, Cruz MEM. Lipid-based nanoformulations of trifluralin analogs in the management of Leishmania infantum infections. Nanomedicine-UK 2016; 11:153-160.
Gaspar MM, Calado S, Pereira J, Ferronha H, Correia I, Castro H, Tomás AM, Cruz MEM. Targeted delivery of paromomycin in murine infectious diseases through association to nano lipid systems. Nanomed-Nanotechnol 2015; 11: 1851-1860.
Carvalheiro M, Esteves MA, Santos-Mateus D, Lopes RM, Rodrigues MA, Eleutério CV, Scoulica E, Santos-Gomes G, Cruz ME. Hemisynthetic trifluralin analogues incorporated in liposomes for the treatment of leishmanial infections. Eur J Pharm Biopharm 2015; 93: 346–352
Lopes RM, Gaspar MM, Pereira J, Eleutério CV, Carvalheiro M, Almeida AJ, Cruz MEM. Liposomes versus lipid nanoparticles: comparative study of lipid-based systems as oryzalin carriers for the treatment of leishmaniasis. J Biomed Nanotechnol 2014; 10: 3647-3657.
Marta G. Silva, Ana Domingos , M. Alexandra Esteves , Maria E.M. Cruz e, Carlos E. Suarez (2013), Evaluation of the growth-inhibitory effect of trifluralin analogues on in vitro cultured Babesia bovis parasites. Int J Parasitol-Drug 2013; 3: 59–68.