Maria Eduarda Romãozinho de Almeida Esteves Mendes

PhD (1998) in Pharmacy (Pharmaceutical Chemistry), Universidade de Lisboa

Assistant Professor, Department of Bromatological and Toxicological Sciences

Faculdade de Farmácia, Universidade de Lisboa — Av. Prof. Gama Pinto, 1649-003 Lisboa, Portugal

T (+351) 217 946 400
F (+351) 217946470
Researcher ID E-1398-2015
Group Researcher ID B-4834-2014
Scopus Author ID 7103403420

Research Interests

Mendes’s work has been related to the chemistry of prodrugs, namely the development of a selective strategy to specifically target triazenes to malignant melanoma cells. The researcher has also developed work in evaluation of new compounds as potential candidates for neurodegenerative diseases. Research has focused on the enzymatic inhibitory activities of some classes of compounds. More recently, the anticancer area of research was enlarged to the synthesis and evaluation of compounds targeting DNA G-quadruplexes.

Selected Publications

Brito H, Martins AC, Lavrado J, Mendes E, Francisco AP, Santos SA, et al. Targeting KRAS Oncogene in Colon Cancer Cells with 7- Carboxylate Indolo[3,2-b]quinoline Tri-Alkylamine Derivatives. PLOS ONE 2015; 10: e0126891.

Mendes E,  Perry MJ,  Francisco AP. Design and discovery of mushroom tyrosinase inhibitors and their therapeutic applications. Expert Opin Drug Discovery 2014; 9: 533-554.

Juárez-Jiménez J,  Mendes E, Galdeano C, Martins C, Silva DB, Marco-Contelles J, Carreiras MC, Luque FJ, Ramsay RR. Exploring the structural basis of the selective inhibition of monoamine oxidase A by dicarbonitrile aminoheterocycles: Role of Asn181 and Ile335 validated by spectroscopic and computational studies. Biochim Biophys Acta 2014; 1844: 389–397.

Monteiro AS, Almeida J, Cabral G, Severino P, Videira PA, Sousa A, Nunes R, Pereira JD, Francisco AP, Perry MJ, Mendes E. Synthesis and evaluation of N-acylamino acids derivativesof triazenes. Activation by tyrosinase in human melanoma cell lines. Eur J Med Chem 2013; 70: 1-9.

Carreiras MC, Mendes E, Perry MJ, Francisco AP and Marco-Contelles J. The Multifactorial Nature of Alzheimer`s Disease for Developing Potential Therapeutics. Curr Top Med Chem 2013; 13: 1745-1770.