Maria de Jesus Perry

PhD (2003) in Pharmacy (Pharmaceutical Chemistry), Universidade de Lisboa
Assistant Professor, Pharmaceutical Chemistry and Organic Chemistry

Faculdade de Farmácia, Universidade de Lisboa — Av. Prof. Gama Pinto, 1649-003 Lisboa, Portugal

T (+351) 217 946 400
F (+351) 217 946 470
Researcher ID E-1746-2015
Group Researcher ID B-4834-2014
Scopus Author ID 55254669000

Research Interests

My area of research in Medicinal Chemistry is focused in Drug Design. Areas of active interest include organic synthesis and identification of biologically active small molecules, prodrugs development, targeted drug delivery, drug metabolism and drug stability. In the recent years I have been involved in the development of hybrid drugs for resistant malignancies namely cancer and malaria.

Science communication activities are another complement that also gives me some rewarding.

 

Selected Publications

 

Capela R, Magalhães J, Miranda D, Machado M, Sanches-Vaz M, Albuquerque IS, Sharma M, Gut J, Rosenthal PJ, Frade R, Perry MJ, Moreira R, Prudêncio M, Lopes F. Endoperoxide-8-aminoquinoline hybrids as dual-stage antimalarial agents with enhanced metabolic stability. Eur J Med Chem 2018; 149:79-68.

Sousa A , Santos F, Gaspar MM, Calado S, Pereira JD, Mendes E, Francisco AP, Perry MJ. The selective cytotoxicity of new triazene compounds to human melanoma cells. Bioorg Med Chem 2017; 25:3900-3910.

Pinheiro R, Braga C, Bronze MR, Perry MJ, Moreira R, Brites D, Falcão AS. Targeting Gliomas: Can a New Alkylating Hybrid Compound Make a Difference? ACS Chem Neurosci 2017; 8: 50-59.

Oliveira R, Miranda D, Magalhães J, Capela R, Perry MJ, O’Neill PM, Moreira R. From Hybrid Compounds to Targeted Drug Delivery in Antimalarial Therapy. Bioorg & Med Chem 2015; 23: 5120-5130.

Rodrigues CA, Frade RF, Albuquerque IS, Perry MJ, Gut J, Machado M, Rosenthal PJ, Prudêncio M, Afonso CA, Moreira R. Targeting the Erythrocytic and Liver Stages of Malaria Parasites with s-Triazine-Based Hybrids. ChemMedChem 2015; 10: 883-890.