Maria Alexandra de Oliveira Silva Braga Pedreira de Brito

Pharm D (1984), Faculdade de Farmácia de Lisboa, PhD (2001) in Pharmacy (Biochemistry), Universidade de Lisboa
Associate Professor (Human Anatomy; Histology and Embriology), Department of Biochemistry and Human Biology, FFULisboa

Faculdade de Farmácia, Universidade de Lisboa — Av. Prof. Gama Pinto, 1649-003 Lisboa, Portugal

T (+351) 217 946 449
F (+351) 217 946 491
Researcher ID M-8278-2013
Group Researcher ID B-5403-2014
Scopus Author ID 7103088772

Research Interests

Brito has studied the mechanisms behind brain dysfunction in ageing and disease (e.g., jaundice, sepsis, Alzheimer’s, and brain metastasis), based on biochemical, morphological and structural analyses of rodents and humans samples, using in vitro, ex vivo and in vivo models. Studies pointed to the blood-brain barrier as a player in neuropathology, both as a source of biomarkers and as a target for modulation, and opened new avenues for the screening of drugs and promising natural compounds for permeation across the blood-brain interface.

Selected Publications

Pogačnik L, Pirc K, Palmela I, Skrt M, Kim KS, Brites D, Brito MA, Ulrih NP, Silva RFM. Potential for brain accessibility and analysis of stability of selected flavonoids in relation to neuroprotection in vitro. Brain Res 2016; 1651: 17-26.

Janota CS, Brites D, Lemere CA, Brito MA. Glio-vascular changes during ageing in wild-type and Alzheimer׳s disease-like APP/PS1 mice. Brain Res 2015; 1620: 153-68.

Palmela I, Correia L, Silva RFM, Sasaki H, Kim KS, Brites D, Brito MA. Hydrophilic bile acids protect human blood-brain barrier endothelial cells from disruption by unconjugated bilirubin: an in vitro study. Front Neurosci 2015: 9: 80.

Brito MA, Pereira P, Barroso C, Aronica E, Brites D. New autopsy findings in different brain regions of a preterm neonate with kernicterus: neurovascular alterations and up-regulation of efflux transporters. Pediatr Neurol 2013; 49: 431-8.

Bernas MJ, Cardoso FL, Daley SK, Weinand ME, Campos AR, Ferreira AJ, Hoying JB, Witte MH, Brites D, Persidsky Y, Ramirez SH, Brito MA. Establishment of primary cultures of human brain microvascular endothelial cells to provide an in vitro cellular model of the blood-brain barrier. Nat Protoc 2010; 5: 1265-72.