Maria Alexandra Brito
PhD (2001) in Pharmacy (Biochemistry), Universidade de Lisboa
Associate Professor, Department of Biochemistry and Human Biology
Faculdade de Farmácia, Universidade de Lisboa — Av. Prof. Gama Pinto, 1649-003 Lisboa, Portugal
Brito has studied the mechanisms behind brain dysfunction in ageing and disease (e.g., jaundice, sepsis, Alzheimer’s, and brain metastasis), based on biochemical, morphological and structural analyses of rodents and humans samples, using in vitro, ex vivo and in vivo models. Studies pointed to the blood-brain barrier as a player in neuropathology, both as a source of biomarkers and as a target for modulation, and opened new avenues for the screening of drugs and promising natural compounds for permeation across the blood-brain interface.
Figueira I, Tavares L, Jardim C, Costa I, Terrasso AP, Mes J, Gardner R, Becker JD, McDougall G, Stewart D, Filipe A, Kim KS, Brites D, Brito C, Brito MA, Santos CN. Blood-brain barrier transport and neuroprotective potential of blackberry-digested polyphenols – an in vitro study. Eur J Nutr 2017 Nov 18. [Epub ahead of print].
Janota CS, Brites D, Lemere CA, Brito MA. Glio-vascular changes during ageing in wild-type and Alzheimer׳s disease-like APP/PS1 mice. Brain Res 2015; 1620: 153-68.
Palmela I, Correia L, Silva RFM, Sasaki H, Kim KS, Brites D, Brito MA. Hydrophilic bile acids protect human blood-brain barrier endothelial cells from disruption by unconjugated bilirubin: an in vitro study. Front Neurosci 2015; 9: 80.
Brito MA, Pereira P, Barroso C, Aronica E, Brites D. New autopsy findings in different brain regions of a preterm neonate with kernicterus: neurovascular alterations and up-regulation of efflux transporters. Pediatr Neurol 2013; 49: 431-8.
Bernas MJ, Cardoso FL, Daley SK, Weinand ME, Campos AR, Ferreira AJ, Hoying JB, Witte MH, Brites D, Persidsky Y, Ramirez SH, Brito MA. Establishment of primary cultures of human brain microvascular endothelial cells to provide an in vitro cellular model of the blood-brain barrier. Nat Protoc 2010; 5: 1265-72.