Margarida Castro Caldas
PhD (2004) in Biology (Cell Biology), Universidade de Coimbra
Assistant Professor, Faculty of Sciences and Technology, Universidade NOVA de Lisboa
Faculdade de Farmácia, Universidade de Lisboa — Av. Prof. Gama Pinto, 1649-003 Lisboa, Portugal
M. Castro-Caldas is interested in the molecular and cellular mechanisms, including post-translational modifications, underlying neurodegeneration and neuroprotection in experimental models of Parkinson’s disease. Work is now being conducted to identify and characterize a neuroprotective agent in Parkinson’s disease. We have recently evaluated its role on the redox state and mitochondrial function, and work aiming to evaluate the role of this molecule on motor function in mouse models of Parkinson’s disease is now being conducted.
Rosa AI, Fonseca I, Nunes MJ, Moreira S, Rodrigues E, Carvalho AN, Rodrigues CMP, Gama MJ, Castro-Caldas M. Novel insights into the antioxidant role of tauroursodeoxycholic acid in experimental models of Parkinson’s disease. Biochim Biophys Acta 2017; 1863: 2171-81.
Moreira S, Fonseca I, Nunes MJ, Rosa AI, Lemos L, Rodrigues E, Carvalho AN, Outeiro TF, Rodrigues CMP, Gama MJ, Castro-Caldas M. Nrf2 activation by tauroursodeoxycholic acid in experimental models of Parkinson’s disease. Exp Neurol 2017; 295: 77-87.
Fonseca I, Gordino G, Moreira S, Nunes MJ, Azevedo C, Gama MJ, Rodrigues E, Rodrigues CMP, Castro-Caldas M. Tauroursodeoxycholic acid protects against mitochondrial dysfunction and cell death via mitophagy in human neuroblastoma cells. Mol Neurobiol 2016 Oct 22 [Epub ahead of print]
Carvalho AN, Marques C, Guedes RC, Castro-Caldas M, Rodrigues E, van Horssen J, Gama MJ. S-Glutathionylation of Keap1: a new role for glutathione S-transferase pi in neuronal protection. FEBS Lett 2016; 590: 1455-66.
Castro-Caldas M, Neves Carvalho A, Rodrigues E, Henderson C, Wolf CR, Gama MJ. Glutathione S-Transferase pi mediates MPTP-induced c-jun N-terminal kinase activation in the nigrostriatal pathway. Mol Neurobiol 2012; 45: 466-77.