Mafalda Marques Videira
PhD (2008) in Pharmacy (Pharmaceutical Technology), Universidade de Lisboa
Assistant Professor, Pharmaceutical Technology, Intellectual Property and Bioethics
Faculdade de Farmácia, Universidade de Lisboa — Av. Prof. Gama Pinto, 1649-003 Lisboa, Portugal
1) Oncological pharmaceutical nanomedicines development and further full characterization of the designed systems. Assessment of properties of the nanoscale developed colloids, focusing in the relation between processes and materials. Applications of the lipid-based carriers for the intracellular deliver of new RNAi strategies against metastatic cancer sub-populations (signaling cascades, intracellular pathways and transcriptional proteins). Interaction between nanoparticles and cellular targets: Intracellular nanoparticles trafficking, in vitro efficacy and toxicity and in vitro/in vivo nanoparticulate system efficacy. Evaluation of pulmonary or mucosal nanoparticles administration and further implications on their lymphatic uptake.
3) Intellectual Property
Silva Lima B, Videira MA. Toxicology and Biodistribution: The Clinical Value of Animal Biodistribution Studies. Mol Ther Methods Clin Dev 2018; 8: 183-197.
Rafael D, Gener P, Andrade F, Seras-Franzoso J, Montero S, Fernández Y, Hidalgo M, Arango D, Sayós J, Florindo HF, Abasolo I, Schwartz S Jr, Videira M. AKT2 siRNA delivery with amphiphilic-based polymeric micelles show efficacy against cancer stem cells. Drug Deliv 2018; 25: 961-972.
Custodio-Santos T, Videira M, Brito MA. Brain metastasization of breast cancer. Biochim Biophys Acta 2017; 1868: 132-147.
Cavaco MC, Pereira C, Kreutzer B, Gouveia LF, Silva-Lima B, Brito AM, Videira M. Evading P-glycoprotein mediated-efflux chemoresistance using Solid Lipid Nanoparticles. Eur J Pharm Biopharm 2017; 110: 76-84.
Arranja A, Gouveia LF, Gener P, Rafael DF, Pereira C, Schwartz S Jr, Videira MA. Self-assembly PEGylation assists SLN-Paclitaxel delivery inducing cancer cell apoptosis upon internalization. International Journal of Pharmaceutics 2016 30; 501: 180-189.