Madalena Maria Vilela Pimentel
PhD (2000) in Pharmacy (Microbiology), Universidade de Lisboa
Associate Professor, Microbiology and Molecular Genetics of Bacteria
Faculdade de Farmácia, Universidade de Lisboa — Av. Prof. Gama Pinto, 1649-003 Lisboa, Portugal
Pimentel is the PI of the scientific program directed to the molecular understanding of the interactions between bacteriophages and Mycobacterium sp. Specifically the group has been focused on the study of the lysis mechanisms induced by mycobacteriophages and in the characterization of the phage proteins that target the mycobacterial cell envelope, aiming the development of new therapeutic approaches. Understanding phage DNA entry and development of tools to study mycobacteria genetics have also been research themes within the group.
Catalão MJ, Gil F, Moniz-Pereira J, São-José C, Pimentel M. Diversity in bacterial lysis systems: bacteriophages show the way. FEMS Microbiol. Rev. 2013; 37: 554-71.
Mestre O, Hurtado-Ortiz R, Dos Vultos T, Namouchi A, Cimino M, Pimentel M, Neyrolles O, Gicquel B. High Throughput Phenotypic Selection of Mycobacterium tuberculosis Mutants with Impaired Resistance to Reactive Oxygen Species Identifies Genes Important for Intracellular Growth. PLoS One 2013; 8: e53486.
Catalão MJ, Milho C, Gil F, Moniz-Pereira J, Pimentel M. A second endolysin gene is fully embedded in-frame with the lysA gene of mycobacteriophage Ms6. PLoS One 2011; 6: e20515.
Catalão MJ, Gil F, Moniz-Pereira J, Pimentel M. Mycobacteriophage Ms6 Encodes a Chaperone–Like Protein Involved in the Endolysin Delivery to the Peptidoglycan. Mol Microbiol 2010; 77: 672-86.
Gil F, Grzegorzewicz AE, Catalão MJ, Vital J, McNeil M, Pimentel M. Mycobacteriophage Ms6 LysB, specifically targets the outer membrane of Mycobacterium smegmatis. Microbiol 2010; 156: 1497-504.