João Perdigão

PhD (2013) in Pharmacy (Microbiology), Universidade de Lisboa
Postdoctoral Fellow, Faculty of Pharmacy, Universidade de Lisboa

Faculdade de Farmácia, Universidade de Lisboa — Av. Prof. Gama Pinto, 1649-003 Lisboa, Portugal

T (+351) 217 934 212
F (+351) 217 946 470
Researcher ID L-6893-2013
Group Researcher ID B-5277-2014
Scopus Author ID 24723211800

Research Interests

The primary research relies on the study of the evolution of Mycobacterium tuberculosis multidrug resistant strains and genomic epidemiology/comparative genomics of clinical isolates circulating in Portugal and Portuguese-speaking countries such as Brazil, Angola, Guinea-Bissau or Mozambique. Additionally, the research area also includes the study of bacterial persistence/latency associated mechanisms leading to drug tolerance in vivo, including global transcriptomic profiling of different M. tuberculosis strains under latency models. Another area of interest lies upon the study of antimicrobial resistance and diversity of Gram-negative bacterial species (e.g. Klebsiella pneumoniae and Neisseria gonorrhoeae) using state of the art High Throughput Sequencing technologies (e.g. Illumina and PacBio).

Selected Publications

Perdigão J, Silva C, Diniz J, Pereira C, Machado D, Ramos J, Silva F, Brum C, Reis AJ, Macedo M, Scaini JL, Silva AB, Esteves L, Macedo R, Maltez F, Clemente S, Coelho E, Viegas S, Rabna P, Rodrigues A, Taveira N, Jordão L, Kritski A, Lapa e Silva J, Mokrousov I, Couvin D, Rastogi N, Couto I, Pain A, McNerney R, Clark TG, von Groll A, Dalla-Costa ER, Rossetti ML, Silva PEA, Viveiros M, Portugal I. Clonal expansion across the seas and CPLP-TB: A Joint Effort in Cataloguing Mycobacterium tuberculosis Genetic Diversity in the Lusophone Space. Infect Genet Evol 2018 in press.

Coll F, Phelan J, Hill-Cawthorne GA, Nair M, Mallard K, Ali S, Abdallah A, Alghamdi S, Alsomali M, Ahmed A, Portelli S, Oppong Y, Alves A, Bessa T, Campino S, Caws M, Chatterjee A, Crampin A, Dheda K, Furnham N, Glynn J, Grandjean L, Há D, Hasan R, Hasan Z, Hibberd M, Joloba M, Jones-López, Matsumoto T, Miranda A, Moore D, Morcillo N, Panaiotov S, Parkhill J, Portugal I, Penha C, Perdigão J, Rchiad Z, Robledo J, Sheen P, Sesha N, Sirgel F, Sola C, Sousa E, Streicher E, Viveiros M, Warren R, McNerney R, Pain A, Clark T. Genome-wide analysis of multi- and extensively drug-resistant Mycobacterium tuberculosis. Nat Genet 2018 50: 764

Perdigão J, Clemente S, Ramos J, Masakidi P, Machado D, Silva C, Couto I, Viveiros M, Taveira N, Portugal I. Genetic diversity, transmission dynamics and drug resistance of Mycobacterium tuberculosis in Angola. Sci Rep 2017; 7: 42814.

Perdigão J, Silva H, Machado D, Macedo R, Maltez F, Silva C, Jordao L, Couto I, Mallard K, Coll F, Hill-Cawthorne GA, McNerney R, Pain A, Clark TG, Viveiros M, Portugal I. Unraveling Mycobacterium tuberculosis genomic diversity and evolution in Lisbon, Portugal, a highly drug resistant setting. BMC Genomics 2014; 15: 991.

Coll F, McNerney R, Guerra-Assunção JA, Glynn JR, Perdigão J, Viveiros M, Portugal I, Pain A, Martin N, Clark TG. A robust SNP barcode for typing Mycobacterium tuberculosis complex strains. Nat Commun 2014; 5: 4812.