João Lavrado

PhD (2010) in Pharmacy (Pharmaceutical Chemistry), Universidade de Lisboa
Post doctoral Research Fellow

Faculdade de Farmácia, Universidade de Lisboa — Av. Prof. Gama Pinto, 1649-003 Lisboa, Portugal

T (+351) 217 946 477
F (+351) 217 946 470
Researcher ID D-6757-2011
Group Researcher ID B-4834-2014
Scopus Author ID 23489277100

Research Interests

Lavrado is a Postdoctoral Researcher engaged in the development of small molecules capable of stabilize or induce DNA G-quadruplex formation, hindering to reduce telomerase activity, responsible to maintain telomeric length in about 85% of all cancers, as well as, to control the transcription of some oncogene. Is research is dedicated to the synthesis of new molecules, based in rational drug design and to the study of their biophysical G-quadruplex binding properties in order to establish structure-activity relationships (SAR).

Selected Publications

Lavrado, J.; Borralho, P. M.; Ohnmacht, S. A.; Castro, R. E.; Rodrigues, C. M.; Moreira, R.; Santos, D. J.; Neidle, S.; Paulo, A. Synthesis, G-Quadruplex Stabilisation, Docking Studies, and Effect on Cancer Cells of Indolo[3,2-b]quinolines with One, Two, or Three Basic Side Chains. ChemMedChem 2013; 8: 1648-1661.

Lavrado, J.; Cabal, G. G.; Prudencio, M.; Mota, M. M.; Gut, J.; Rosenthal, P. J.; Diaz, C.; Guedes, R. C.; Dos Santos, D. J.; Bichenkova, E.; Douglas, K. T.; Moreira, R.; Paulo, A. Incorporation of Basic Side Chains into Cryptolepine Scaffold: Structure-Antimalarial Activity Relationships and Mechanistic Studies. J Med Chem 2011; 54: 734–750.

Lavrado, J.; Reszka, A. P.; Moreira, R.; Neidle, S.; Paulo, A. C-11 diaminocryptolepine derivatives NSC748392, NSC748393 and NSC748394: Anticancer profile and G-quadruplex stabilization. Bioorg Med Chem Lett 2010; 20: 7042-7045.

Lavrado, J.; Moreira, R.; Paulo, A. Indoloquinolines as Scaffolds for Drug Discovery. Curr Med Chem 2010; 17: 2348-2370.