PhD (1999) in Pharmacy (Microbiology), Universidade de Lisboa
Assistant Professor, Microbiology
Faculdade de Farmácia, Universidade de Lisboa — Av. Prof. Gama Pinto, 1649-003 Lisboa, Portugal
Our group investigates the genetic diversity of Mycobacterium tuberculosis strains and evaluates the proportion of recently transmitted disease between patients. We focus on identifying factors responsible for dissemination of particular strains and its capacity for adapting and increase pathogenicity and virulence. Evaluation of the distribution of various mutations related to drug resistance, in predominant clinical strains as permitted the selection of a limited number of target mutations, allowing the development of a rapid method of identification and detection of such a strains.
Perdigão J, Macedo R, Ribeiro A, Brum L, Portugal I. Genetic characterization of the ethambutol resistance determinating region in Mycobacterium tuberculosis: prevalence and significance of embB306 mutations. International Journal of Antimicrobial Agents 2009. 33(4):334-8.
Perdigão J, Macedo R, Malaquias A, Ferreira A, Brum L, Portugal I. Genetic Analysis of Extensive Drug-Resistant Mycobacterium tuberculosis in Lisbon, Portugal. Journal of Antimicrobial Chemotherapy 2010. 65(2):224-7.
Perdigão J, Macedo R, Silva C, Pinto C, Furtado C, Brum L, Portugal I. Tuberculosis Drug-Resistance in Lisbon, Portugal: a Six-Year Overview. Clinical Microbiology and Infection 2011. 17(9):1397-402.
Perdigão J, Macedo R, Silva C, Machado D, Couto I, Viveiros M, Jordão L, Portugal I. From multidrug-resistant to extensively drug-resistant tuberculosis in Lisbon, Portugal: the stepwise mode of resistance acquisition. Journal of Antimicrobial Chemotherapy 2013. 68(1):27-33.
Perdigão J, Macedo R, Machado D, Silva C, Jordão L, Couto I, Viveiros M, Portugal I. GidB mutation as a phylogenetic marker for Q1 cluster Mycobacterium tuberculosis isolates and intermediate-level streptomycin resistance determinant in Lisbon, Portugal. Clin Microbiol Infect. 2013 Sep 14. [Epub ahead of print]