Hélio Manuel Ferreira Faustino

PhD (2014) in Chemical science and technology, Universidade de Santiago de Compostela

Pos-doc at Gois lab, Universidade de Lisboa

Faculdade de Farmácia, Universidade de Lisboa — Av. Prof. Gama Pinto, 1649-003 Lisboa, Portugal

Researcher ID E-1903-2012
Group Researcher ID B-4209-2014
Scopus Author ID 25121396900

Research Interests

Hélio Faustino is a postdoc at the Gois lab and he is currently working in the “Design of iminoboronate based antitumor targeting conjugates”, developing generic synthetic methods to modified peptides and proteins. In this context recently the group disclosed a method for selective, rapid and reversible N-terminal cysteine functionalisation. Previous works include metal catalysis, in particular Gold catalyzed cycloadditions.

Selected Publications

Faustino H, Silva MJSA, Veiros LF, Bernardes GJL, Gois PMP. Iminoboronates are efficient intermediates for selective, rapid and reversible N -terminal cysteine functionalisation. Chem Sci. 2016;7(8):5052-5058.

Destito P, R. Couceiro J, Faustino H, Lopez F, Mascareñas JL. Ruthenium-Catalyzed Azide-Thioalkyne Cycloadditions in Aqueous Media (RuAtAC): A Mild, Orthogonal and Biocompatible Chemical Ligation. Angew Chemie Int Ed. July 2017. [Epub ahead of print]

Faustino H, Varela I, Mascareñas JL, López F. Gold(I)-catalyzed [2 + 2 + 2] cycloaddition of allenamides, alkenes and aldehydes: a straightforward approach to tetrahydropyrans. Chem Sci. 2015;6(5):2903-2908.

Faustino H, Alonso I, Mascareñas JL, López F. Gold(I)-Catalyzed Cascade Cycloadditions between Allenamides and Carbonyl-Tethered Alkenes: An Enantioselective Approach to Oxa-Bridged Medium-Sized Carbocycles. Angew Chemie Int Ed. 2013;52(25):6526-6530.

Faustino H, López F, Castedo L, Mascareñas JL. Gold(I)-catalyzed intermolecular (4 + 2) cycloaddition of allenamides and acyclic dienes. Chem Sci. 2011;2(4):633.