Helena F. Florindo
PhD (2008) in Pharmacy (Pharmaceutical Technology), Universidade de Lisboa
Assistant Professor, Pharmaceutics and Pharmaceutical Technology
Faculdade de Farmácia, Universidade de Lisboa — Av. Prof. Gama Pinto, 1649-003 Lisboa, Portugal
Florindo’s research is focused on the development of multivalent nanotechnology-based systems to modulate the recognition, capture, processing and presentation of cancer antigens by dendritic cells. It includes the in vitro and in vivo studies of the anti-tumor effects induced by the combination of these nanovaccines with nanotherapeutics designed to modulate the function and activation of other key cells within tumor site, such as T cells, myeloid-derived cells and tumor cells.
Silva JM, Zupancic E, Vandermeulen G, Oliveira V, Salgado A, Videira M, Gaspar M, Graça L, Préat V, Florindo HF. In vivo delivery of peptides and Toll-like receptor ligands by mannose-functionalized polymeric nanoparticles induces prophylactic and therapeutic anti-tumour immune responses in a melanoma model. J Control Release 2015; 198C; 91-103.
Zupančič E, Curato C, Paisana M, Rodrigues C, Porat Z, Viana AS, Afonso CA, Pinto J, Moreira JN, Gaspar R, Satchi-Fainaro R, Jung S, Florindo HF. Rational design of nanoparticles towards targeting antigen-presenting cells and improved T cell priming. J Control Release 2017; 28: 182-195.
Silva AL, Peres C, Conniot J, Matos AI, Moura L, Carreira B, Sainz V, Scomparin A, Satchi-Fainaro R, Préat V, Florindo HF. Nanoparticle impact on innate immune cell pattern-recognition receptors and inflammasomes activation. Semin Immunol 2017; pii: S1044-5323(17)30040-4.
Santos FMF, Matos AI, Ventura AE, Gonçalves J, Veiros LF, Florindo HF, Gois PMP. Modular Assembly of Reversible Multivalent Targeting Drug Conjugates. Angewandte Chemie 2017 56(32):9346-9350.
Silva JM, Videira M, Gaspar R, Préat V, Florindo HF. Immune System Targeting by Nanoparticles for Cancer Vaccines. J Control Release 2013; 168: 179-199.