Helder Mota-Filipe

PhD (1996) in Pharmacy (Pharmacology), Universidade de Lisboa
Associate Professor, Pharmacology and Therapeutics
Vice-President, National Authority for Medicines and Health Products (INFARMED, IP)
Member of the Management Board, European Medicines Agency (EMA)

Faculdade de Farmácia, Universidade de Lisboa — Av. Prof. Gama Pinto, 1649-003 Lisboa, Portugal

T (+351) 217 987 117
F (+351) 217 946 470
Researcher ID M-6298-2013
Group Researcher ID B-5723-2014
Scopus Author ID 6604005426

Research Interests

Mota-Filipe leads a group (Pharmacology & Translational Research) performing research on novel innovative therapeutic approaches for human diseases in the areas of shock, sepsis and inflammation. Areas of research include neuroprotection for transient focal cerebral ischemia, new targets for the modulation of acute lung injury, inflammatory bowel disease or pharmacological interventions on ischemia-reperfusion injury and dysfunction. Mota-Filipe is also interested on the application of its research in early stages of drug discovery programs.

Selected Publications

Dias T, Liu B, Jones P, Houghton PJ, Mota-Filipe H, Paulo A. Cytoprotective effect of Coreopsis tinctoria extracts and flavonoids on tBHP and cytokine-induced cell injury in pancreatic MIN6 cells. J Ethnopharmacol. 2012; 139:485-92

Maio R, Sepodes B, Patel NS, Thiemermann C, Mota-Filipe H, Costa P. Erythropoietin preserves the integrity and quality of organs for transplantation after cardiac death. Shock. 2011; 35:126-33

Milsom AB, Patel NS, Mazzon E, Tripatara P, Storey A, Mota-Filipe H, Sepodes B, Webb AJ, Cuzzocrea S, Hobbs AJ, Thiemermann C, Ahluwalia A. Role for endothelial nitric oxide synthase in nitrite-induced protection against renal ischemia reperfusion injury in mice. Nitric Oxide. 2010; 22: 141-8

Kapoor A, Shintani Y, Collino M, Osuchowski MF, Busch D, Patel NS, Sepodes B, Castiglia S, Fantozzi R, Bishop-Bailey D, Mota-Filipe H, Yaqoob MM, Suzuki K, Bahrami S, Desvergne B, Mitchell JA, Thiemermann C. Protective role of peroxisome proliferator-activated receptor-β/δ in septic shock. Am J Respir Crit Care Med. 2010; 182: 1506-15

Rauter AP, Martins A, Borges C, Mota-Filipe H, Pinto R, Sepodes B, Justino, Antihyperglycaemic and protective effects of flavonoids on streptozotocin-induced diabetic rats. J Phytother Res 2010; 24: S133-8