Graça Soveral

PhD (1995) in Pharmacy (Biochemistry), Universidade de Lisboa
Associate Professor (with Habilitation), Biochemistry and Human Biology

Faculdade de Farmácia, Universidade de Lisboa — Av. Prof. Gama Pinto, 1649-003 Lisboa, Portugal

T (+351) 217 946 461
F (+351) 217 946 470
Researcher ID L-1550-2013
Group Researcher ID B-5293-2014
Scopus Author ID 6602417900

Research Interests

G Soveral is group leader of the Biological Transport Group (BioLTransp) dedicated to the study of membrane transport in biological systems. Our interests are (i) understanding membrane transport phenomena and mechanisms underlying transporters defects that may lead to disease, (ii) identifying transport systems as targets for drug action, (iii) screening of compounds as modulators of channels and transporters, with emphasis on aquaporin regulation and discovery of aquaporin inhibitors for diagnostic and therapeutic applications.

Selected Publications

Direito I, Paulino J., Vigia E, Brito MA, Soveral G. Differential expression of aquaporin-3 and aquaporin-5 in pancreatic ductal adenocarcinoma. J Surg Oncol 2017 [Epub ahead of print] doi: 10.1002/jso.24605

Soveral G, Casini A. Aquaporin modulators: a patent review (2010-2015). Expert Opin Ther Pat 2017; 27(1): 49-60.

de Almeida A, Mósca AF, Wragg D, Wenzel M, Kavanagh P, Barone G, Leoni S, Soveral G, Casini A. The mechanism of aquaporin inhibition by gold compounds elucidated by biophysical and computational methods. Chem Commun (Camb) 2017; 53: 3830—3833.

Madeira A, Moura TF, Soveral G. Detecting aquaporin function and regulation. Front. Chem 2016; 4:3.

Madeira A, Moura TF, Soveral G. Aquaglyceroporins: implications in adipose biology and obesity. Cell Mol Life Sci 2015; 2:759–771.