Francisca da Conceição Lopes
PhD (2000) in Pharmacy (Pharmaceutical Chemistry), Universidade de Lisboa
Associate Professor, Pharmaceutical and Medicinal Chemistry
Faculdade de Farmácia, Universidade de Lisboa — Av. Prof. Gama Pinto, 1649-003 Lisboa, Portugal
Lopes is involved in the design of antimalarial agents targeting several stages of the malaria parasite’s life-cycle. She pioneered the use of the hybrid drug concept in antimalarial drug discovery. Lopes is developing pro-drugs as targeted delivery systems based on parasite-selective mechanisms such as the Fe(II)-triggered activation of endoperoxides. Currently, she is translating this concept to target Leishmania parasites and to develop tumor activated pro-drugs.
Oliveira R, Guedes RC, Meireles P, Albuquerque IS, Gonçalves LM, Pires E, Bronze MR, Gut J, Rosenthal PJ, Prudêncio M, Moreira R, O’Neill PM, Lopes F. Tetraoxane-Pyrimidine Nitrile Hybrids as Dual Stage Antimalarials. J. Med. Chem. 2014, 57, 4916-4923.
Miranda D, Capela R, Albuquerque IS, Meireles P, Paiva I, Nogueira F, Amewu R, Gut J, Rosenthal PJ, Oliveira R, Mota MM, Moreira R, Marti F, Prudêncio M, O’Neill P, Lopes F. Novel endoperoxide-based transmission-blocking antimalarials with liver- and blood-schizontocidal activities. ACS Med. Chem. Lett. 2014, 5, 108-112.
Oliveira R, Newton AS, Guedes RC, Miranda D, Amewu RK, Srivastava A, Gut J, Rosenthal PJ, O’Neill PM, Ward SA, Lopes F, Moreira R. An Endoperoxide-Based Hybrid Approach to Deliver Falcipain Inhibitors Inside Malaria Parasites. ChemMedChem, 2013, 8, 1528- 1536.
Rodrigues T, da Cruz FP, Prudêncio M, Mota MM, Gut J, Rosenthal PJ, Moreira R, Lopes F. Flavones as isosteres of 4(1H)-quinolones: discovery of ligand efficient and dual stage antimalarial lead compounds. Eur. J. Med. Chem. 2013,69, 872-880.
Ressurreição AS, Gonçalves D, Sitoe AR, Albuquerque IS, Gut J, Góis A, Gonçalves LM, Bronze MR, Hanscheid T, Biagini GA, Rosenthal PJ, Prudêncio M, O’Neill P, Mota MM, Lopes F, Moreira R. Structural optimization of quinolon-4(1H)-imines as dual-stage antimalarials: towards increased potency and metabolic stability. J. Med. Chem. 2013, 56, 7679-7690.