Francisca da Conceição Lopes
PhD (2000) in Pharmacy (Pharmaceutical Chemistry), Universidade de Lisboa
Associate Professor, Pharmaceutical and Medicinal Chemistry
Faculdade de Farmácia, Universidade de Lisboa — Av. Prof. Gama Pinto, 1649-003 Lisboa, Portugal
Lopes’ research includes the design of new antimalarial drugs targeting validated therapeutic targets. Current investigation is focused on the haeme polymerization and mitochondrial electron transport processes. Both processes are essential for the survival and development of malaria parasites and thus the design of compounds that block these pathways are obvious antimalarial drug candidates.Another major interest is the development of hybrid drugs, i.e. compounds targeting different stages of the malaria parasites’ life cycle.
Miranda D, Capela R, Albuquerque I, Meireles P, Paisa I, Nogueira F, Amewu R, Gut J, Rosenthal PJ, Oliveira R, Mota MM, Moreira R, Marti F, Prudêncio M, O’Neill PM, and Lopes F.Novel Endoperoxide-Based Transmission-Blocking Antimalarials with Liver- and Blood-Schizontocidal Activities. ACS Med Chem Lett In press; DOI: 10.1021/ml4002985.
Rodrigues T,Ressurreição AS, Da Cruz FP,Albuquerque IS, Gut J, Carrasco MP,Gonçalves D,Guedes RC, Dos Santos DJVA,Mota MM, Rosenthal PJ, Moreira R,Prudêncio M and Lopes F.Flavones as isosteres of 4(1H)-quinolones: Discovery of ligand efficient and dual stage antimalarial lead compounds. Eur J Med Chem 2013; 69: 872-880.
Ressurreição AS, Gonçalves D,Sitoe AR, Albuquerque IS, Gut J,Góis A,Gonçalves LM,Bronze MR,Hanscheid T,Biagini GA,Rosenthal PJ,Prudêncio M,ONeill PM,Mota MM, Lopes F and Moreira R.Structural optimization of quinolon-4(1H)-imines as dual-stage antimalarials: Toward increased potency and metabolic stability. J Med Chem 2013; 56: 7679-7690.
Rodrigues T, da Cruz FP, Lafuente-Monasterio M, Gonçalves D, Ressurreição AS, Sitoe AR, Bronze MR, Gut J, Schneider G, Mota MM, Rosenthal PJ, Prudêncio M, Gamo FJ, Lopes F, Moreira R. Quinolon-4(1H)-imines are potent antiplasmodial drugs targeting the liver stage of malaria. J Med Chem 2013; 56: 4811-4815.
Capela R, Cabal GG,Rosenthal PJ,Gut J,Mota MM, Moreira R, Lopes F and Prudêncio M. Design and evaluation of primaquine-artemisinin hybrids as a multistage antimalarial strategy. Antimicrob Agents Ch 2011; 55: 4698-4706.