PhD (1988) in Pharmacy (Biochemistry), Universidade de Lisboa
Coordinator Researcher, Faculdade de Farmácia, Universidade de Lisboa (FFULisboa)
Invited Full Professor (Neurobiology; Histology and Embriology), Department of Biochemistry and Human Biology (FFULisboa)
Faculdade de Farmácia, Universidade de Lisboa — Av. Prof. Gama Pinto, 1649-003 Lisboa, Portugal
The group headed by Brites investigates neuron-glia (microglia, astrocytes & oligodendrocytes) deregulated communication, including secretome pathological material and exosome-miRNAs, in neurodegenerative disorders (AD, ALS & MS) and brain metastasis. Patient-derived iPSCs and biological samples, genetically engineered mice and in-vivo/ex-vivo/in-vitro 2D/3D models are used to assess senescence, neuroinflammation and BBB-leakage processes. The goal is to uncover disease mechanisms, early biomarkers, targets and neuroprotective therapeutics.
Cunha C, Santos C, Gomes C, Fernandes A, Correia AM, Sebastião AM, Vaz AR, Brites D. Downregulated glia interplay and increased miRNA-155 as promising markers to track ALS at an early stage. Mol Neurobiol 2017. [Epub ahead of print].
Pinto S, Cunha C, Barbosa M, Vaz AR, Brites D. Exosomes from NSC-34 cells transfected with hSOD1-G93A are enriched in miR-124 and drive alterations in microglia phenotype. Front Neurosci 2017; 11: 273.
Falcão AS, Carvalho LA, Lidónio G, Vaz AR, Lucas SD, Moreira R, Brites D. Dipeptidyl vinyl sulfone as a novel chemical tool to inhibit HMGB1/NLRP3-inflammasome and inflamma-miRs in Aβ-mediated microglial inflammation. ACS Chem Neurosci 2017; 8: 89-99.
Cardoso FL, Herz J, Fernandes A, Rocha J, Sepodes B, Brito MA, McGavern DB, Brites D. Systemic inflammation in early neonatal mice induces transient and lasting neurodegenerative effects. J Neuroinflammation 2015; 12: 82.
Fernandes A, Barateiro A, Falcão AS, Silva SL, Vaz AR, Brito MA, Silva RFM, Brites D. Astrocyte reactivity to unconjugated bilirubin requires TNF-alpha and IL-1beta receptor signaling pathways. Glia 2011; 59: 14-25.