David Pires

PhD (2014) in Pharmacy (Cellular and Molecular Biology), Universidade de Lisboa

Post-Doctoral Fellow, iMed.ULisboa, Faculdade de Farmácia, Universidade de Lisboa

Faculdade de Farmácia, Universidade de Lisboa — Av. Prof. Gama Pinto, 1649-003 Lisboa, Portugal

T (+351) 217 946 400
F (+351) 217946470
Researcher ID D-8245-2012
Group Researcher ID B-4239-2014
Scopus Author ID 50162243000

Research Interests

Host-pathogen interactions during M. tuberculosis and HIV infection of host immune cells. These pathogens manipulate host cells at different stages of infection inhibiting cellular processes and resisting antimicrobial mechanisms. I have been focusing my studies on finding new mechanisms and drugs that allow us to manipulate the host cellular response to infection while also targeting the pathogen itself. This dual-approach to infection reduces the probability of emergence of new drug resistant strains and improves the conventional therapy.

Selected Publications

Pires D, Bernard EM, Pombo JP, Carmo N, Fialho C, Gutierrez MG, Bettencourt P, Anes E. Mycobacterium tuberculosis Modulates miR-106b-5p to Control Cathepsin S Expression Resulting in Higher Pathogen Survival and Poor T-Cell Activation. Front Immunol 2017; 8: 1819.

Pires D, Marques J, Pombo JP, Carmo N, Bettencourt P, Neyrolles O, Lugo-Villarino G, Anes E. Role of Cathepsins in Mycobacterium tuberculosis Survival in Human Macrophages. Sci Rep 2016; 6: 32247

Machado D, Pires D, Perdigão J, Couto I, Portugal I, Martins M, Amaral L, Anes E, Viveiros M. Ion Channel Blockers as Antimicrobial Agents, Efflux Inhibitors, and Enhancers of Macrophage Killing Activity against Drug Resistant Mycobacterium tuberculosis. PLoS One 2016; 11: e0149326.

Vibe CB, Fenaroli F, Pires D, Wilson SR, Bogoeva V, Kalluru R, Speth M, Anes E, Griffiths G, Hildahl J. Thioridazine in PLGA nanoparticles reduces toxicity and improves rifampicin therapy against mycobacterial infection in zebrafish. Nanotoxicology. 2016; 17: 680–8.

Pires D, Valente E, Simões MF, Carmo N, Testa B, Constantino L, Anes E. Esters of Pyrazinoic Acid Are Active against Pyrazinamide-Resistant Strains of Mycobacterium tuberculosis and Other Naturally Resistant Mycobacteria In Vitro and Ex Vivo within Macrophages. Antimicrob Agents Chemother 2015; 59: 7693–9.