Faculdade de Farmácia, Universidade de Lisboa — Av. Prof. Gama Pinto, 1649-003 Lisboa, Portugal
The main research focus has been the safety and health effects of bioactive compounds from marine, plant and food sources in animal models of metabolic (including diabetes), bone and skin disorders.
Recently interests have broadened to aspects such as cognitive dysfunction and the safety of new psychoactive and old drugs and since the European project NPS-Euronet to the in vitro/in vivo metabolism studies.
De Mello-Sampayo C, Agripino AA, Stilwell D, Vidal B, Fernando AL, Silva-Lima B, Vaz MF, Canhão H, Marques MC. Chronic Hyperglycemia Modulates Rat Osteoporotic Cortical Bone Microarchitecture into Less Fragile Structures. Int J Endocrinol 2017; 4603247.
Sponchiado G, Adam ML, Silva CD, Silva Soley B, De Mello-Sampayo C, Cabrini DA, Correr CJ, Otuki MF. Quantitative genotoxicity assays for analysis of medicinal plants: A systematic review. J Ethnopharmacol 2016; 178:289-296.
Encarnação S, de Mello-Sampayo C, Graça NAG, Catarino L, da Silva IBM, Lima BS, Silva OMD. Total phenolic content, antioxidant activity and pre-clinical safety evaluation of an Anacardium occidentale stem bark Portuguese hypoglycemic traditional herbal preparation. Industrial Crops and Products 2016; 82: 171-178.
Barcelos RCS, de Mello-Sampayo C, Antoniazzi CTD, Segat HJ, Silva H, Veit JC, Piccolo J, Emanuelli T, Bürger ME, Silva-Lima B, Rodrigues LM. Oral supplementation with fish oil reduces dryness and pruritus in the acetone-induced dry skin rat model. J Dermatol Sci 2015; 79: 298-304.
de Mello-Sampayo C, Corvo ML, Mendes R, Duarte D, Lucas J, Pinto R, Batista AP, Raymundo A, Silva-Lima B, Bandarra NM, Gouveia L. Insights on the safety of carotenogenic Chlorella vulgaris in rodents. Algal Res 2013; 2: 409-415.