Cristina Maria Leitão de Carvalho

PhD in Biotechnology (1999) IST, UTL, Lisbon
Associate Professor (Toxicology), Department of Toxicology and Food Sciences, Faculty of Pharmacy, University of Lisbon

Faculdade de Farmácia, Universidade de Lisboa — Av. Prof. Gama Pinto, 1649-003 Lisboa, Portugal

T (+351) 217 946 400
F (+351) 217 946 470
Researcher ID E-3379-2014
Group Researcher ID B-4215-2014
Scopus Author ID 35553159800

Research Interests

Cristina Carvalho leads investigation on biomarkers and molecular mechanisms of toxicity involving the thioredoxin system and other antioxidant systems. The applications span from metals toxicity (mercury) to disease therapy (for instance, cancer). Her focus is on identifying mechanism-based molecular targets to understand toxicity development and/or to purpose therapeutic intervention, using relevant in vitro models, human biological samples, and molecular and cell biology approaches. The research aims at contributing to Human and Environmental Risk Assessment and includes the exposure assessment of populations at risk.

Selected Publications

Branco V, Canário J, Jun L, Holmgren A, Carvalho, C. 2012. In vivo interaction between mercury compounds and selenium: effects on thioredoxin reductase and glutathione peroxidase. Free Radical Biology & Medicine 2012; 52:781–793.

Branco V, Canário J, Holmgren A, Carvalho, C. 2011. Inhibition of the Thioredoxin System in the Brain and Liver of Zebra-Seabreams Exposed to Waterborne Methylmercury. Toxicology and Applied Pharmacology 2011; 251: 95-103.

Carvalho C, Lu J, Zhang X, Arnér E, Holmgren A. 2011. Effects of selenite and chelating agents on mammalian thioredoxin reductase inhibited by mercury: implications for treatment of mercury poisoning. The FASEB Journal 2011; 25: 370-381.

Carvalho CML, Chew E-H, Hashemy SI, Lu J, Holmgren A.  2008. Inhibition of Human Thioredoxin System: a molecular mechanism of mercury toxicity. Journal of Biological Chemistry 2008; 283: 11913-11923.

Carvalho CML, Matos AINM, Mateus ML, Santos APM, Batoréu MCC. 2008. High-fish consumption and risk prevention: Exposure assessment to methylmercury in Portugal. Journal of Toxicology and Environmental Health 2008; Part A, 71: 1279-1288.