Cecília M. P. Rodrigues
PhD (1996) in Pharmacy (Biochemistry), Universidade de Lisboa
Postdoctoral research at University of Minnesota, USA
Full Professor, Biochemistry and Human Biology, Faculdade de Farmácia, Universidade de Lisboa
Faculdade de Farmácia, Universidade de Lisboa — Av. Prof. Gama Pinto, 1649-003 Lisboa, Portugal
Rodrigues leads a group investigating molecular regulatory aspects of cell function in disease processes (metabolic, degenerative, cancer), with pioneer studies in bile acid-related research. Her laboratory focuses on identifying mechanism-based molecular targets for therapeutic intervention and biomarkers, using relevant preclinical disease models as well as patient samples, available via collaborations with various hospitals. Transcriptome and proteome profiles are validated using genetic or pharmacological modulation in vitro and in mice. Finally, discovery of novel therapies and biomarkers include strategies such as high throughput molecular bioscreening and preclinical modelling of disease. Rodrigues has developed bile acids as a group of promising small molecule modulators of cell death/survival, protected by patents and licensed by spin-offs.
Afonso MB, Rodrigues PM, Simão A, Gaspar M, Carvalho T, Nunes P, Banales J, Castro RE, Rodrigues CMP. miRNA-21 is overexpressed in primary biliary cholangitis and contributes to liver injury and necroptosis in bile duct-ligated mice. Cell Death Differ 2018; 25 :857-872.
Rodrigues PM, Afonso MB, Simão AL, Carvalho CC, Trindade A, Duarte A, Borralho PM, Machado MV, Cortez-Pinto H, Rodrigues CMP, Castro RE. miR-21 ablation and obeticholic acid ameliorate non-alcoholic steatohepatitis in mice. Cell Death Dis 2017; 8: e2748.
Afonso MB, Rodrigues PM, Simão AL, Ofengeim D, Carvalho T, Amaral JD, Gaspar MM, Cortez-Pinto H, Castro RE, Yuan J, Rodrigues CMP. Activation of necroptosis in human and experimental cholestasis. Cell Death Dis 2016; 7: e2390.
Castro RE, Ferreira DMS, Borralho PM, Machado MV, Cortez-Pinto H, Rodrigues CMP. miR-34a/SIRT1/p53 is suppressed by ursodeoxycholic acid in rat liver and activated by disease severity in human non-alcoholic fatty liver disease. J Hepatol 2013; 58: 119-25.
Rodrigues CMP, Solá S, Nan Z, Castro RE, Ribeiro PS, Low WC, Steer CJ. Tauroursodeoxycholic acid reduces apoptosis and protects against neurologic injury after acute hemorrhagic stroke in rats. Proc Natl Acad Sci USA 2003; 100: 6087-92.