PhD in Molecular Biology (2002)
Assistant Professor (Dpt. of Microbiology and Immunology, FFULisboa)
Faculdade de Farmácia, Universidade de Lisboa — Av. Prof. Gama Pinto, 1649-003 Lisboa, Portugal
C. São-José research is focused on virus/host cell interactions in prokaryotic systems, both with fundamental and applied purposes. One of C. São-José’s research interests is to understand the mode of action and regulation of the lytic proteins that bacteriophages employ to destroy the bacterial cell envelope, and to explore this knowledge to engineer agents to fight antibiotic-resistant bacteria. C. São-José also collaborates with the company TechnoPhage in the development of phage-based antibacterial products for therapeutic purposes.
São-José C. Engineering of Phage-Derived Lytic Enzymes: Improving Their Potential as Antimicrobials. Antibiotics (Basel) 2018; 7 pii: E29.
Fernandes S, São-José C. More than a hole: the holin lethal function may be required to fully sensitize bacteria to the lytic action of canonical endolysins. Mol Microbiol 2016; 102: 92-106.
Proença D, Leandro C, Garcia M, Pimentel M, São-José C. EC300: a phage-based, bacteriolysin-like protein with enhanced antibacterial activity against Enterococcus faecalis. Appl Microbiol Biotechnol 2015; 99: 5137-49.
Proença D, Velours C, Leandro C, Garcia M, Pimentel M, São-José C. A two-component, multimeric endolysin encoded by a single gene. Mol Microbiol 2015; 95: 739-53.
Catalão MJ, Gil F, Moniz-Pereira J, São-José C, Pimentel M. Diversity in bacterial lysis systems: bacteriophages show the way. FEMS Microbiol Rev 2013; 37: 554-71.