Carlos São-José

PhD (2002) in Molecular Biology, Universidade de Lisboa
Assistant Professor, Microbiology and Immunology, Faculdade de Farmácia, Universidade de Lisboa

Faculdade de Farmácia, Universidade de Lisboa — Av. Prof. Gama Pinto, 1649-003 Lisboa, Portugal

T (+351) 217 946 420
F (+351) 217 986 055
Researcher ID J-6703-2012
Group Researcher ID B-5277-2014
Scopus Author ID 6507498924

Research Interests

C. São-José research is focused on virus/host cell interactions in prokaryotic systems, both with fundamental and applied purposes. One of C. São-José’s research interests is to understand the mode of action and regulation of the lytic proteins that bacteriophages employ to destroy the bacterial cell envelope, and to explore this knowledge to engineer agents to fight antibiotic-resistant bacteria. C. São-José also collaborates with the company TechnoPhage in the development of phage-based antibacterial products for therapeutic purposes.

Selected Publications

São-José C. Engineering of Phage-Derived Lytic Enzymes: Improving Their Potential as Antimicrobials. Antibiotics (Basel) 2018; 7 pii: E29.

Fernandes S, São-José C. More than a hole: the holin lethal function may be required to fully sensitize bacteria to the lytic action of canonical endolysins. Mol Microbiol 2016; 102: 92-106.

Proença D, Leandro C, Garcia M, Pimentel M, São-José C. EC300: a phage-based, bacteriolysin-like protein with enhanced antibacterial activity against Enterococcus faecalis. Appl Microbiol Biotechnol 2015; 99: 5137-49.

Proença D, Velours C, Leandro C, Garcia M, Pimentel M, São-José C. A two-component, multimeric endolysin encoded by a single gene. Mol Microbiol 2015; 95: 739-53.

Catalão MJ, Gil F, Moniz-Pereira J, São-José C, Pimentel M. Diversity in bacterial lysis systems: bacteriophages show the way. FEMS Microbiol Rev 2013; 37: 554-71.