Carlos Jorge Sousa de São José

PhD in Molecular Biology (2002)
Assistant Professor (Dpt. of Microbiology and Immunology, FFULisboa)

Faculdade de Farmácia, Universidade de Lisboa — Av. Prof. Gama Pinto, 1649-003 Lisboa, Portugal

T (+351) 217 946 420
F (+351) 217 986 055
Researcher ID J-6703-2012
Group Researcher ID B-5277-2014
Scopus Author ID 6507498924

Research Interests

C. São-José leads a group dedicated to the study of virus/host cell interactions in prokaryotic systems, both with fundamental and applied purposes. Current topics are:
1. Molecular and biophysical bases of bacteriophage DNA ejection into host cells;
2. Development of phage-based vectors for cell-targeted DNA delivery;
3. Regulation of bacterial lysis mediated by bacteriophages;
4. Design of phage-based antibacterial products (in collaboration with the company Technophage, SA);
5. Functioning and cellular role of an Esat-6-like secretion system.

Selected Publications

Baptista, C., Barreto H.C. and São-José, C. (2013). High levels of DegU-P activate an Esat-6-Like secretion system in Bacillus subtilis. PLoS ONE. 8: e67840.

Catalão, M.J., Gil, F., Moniz-Pereira, J., São-José, C. and Pimentel, M. (2013). Diversity in bacterial lysis systems: bacteriophages show the way. FEMS Microbiol. Rev. 37: 554-571.

Fernandes, S., Proença, D., Cantante, C., Silva, F.A., Leandro, C., Lourenço, S.,  Milheiriço, C., de Lencastre, H., Cavaco-Silva, P., Pimentel, M. and São-José, C. (2012). Novel Chimerical Endolysins with Broad Antimicrobial Activity against Methicillin-Resistant Staphylococcus aureus. Microb. Drug Resist. 18: 333-343.

Vinga, I., Baptista, C., Auzat, I., Petipas, I., Lurz, R., Tavares, P., Santos, M.A. and São-José, C. (2012). Role of bacteriophage SPP1 tail spike protein gp21 on host cell receptor binding and trigger of phage DNA ejection. Mol. Microbiol. 83: 289-303.

São-José, C., Lhuillier, S., Lurz, R., Melki, R., Lepault, J., Santos, M.A. and Tavares, P. (2006). The ectodomain of the viral receptor YueB forms a fiber that triggers ejection of the bacteriophage SPP1 DNA. J. Biol. Chem. 281: 11464-11470.