Andreia Neves Carvalho
PhD (2012) in Pharmacy (Biochemistry), Universidade de Lisboa
Postdoctoral Fellow, VU University Medical Center, Amsterdam, The Netherlands
Post-Doctoral Fellow (FCT), iMed.ULisboa, Faculdade de Farmácia, Universidade de Lisboa
Faculdade de Farmácia, Universidade de Lisboa — Av. Prof. Gama Pinto, 1649-003 Lisboa, Portugal
My main research focus is on the characterization of the molecular mechanisms underlying mitochondrial dysfunction, oxidative stress/endoplasmic reticulum stress and associated neuro-axonal damage leading to neurodegeneration. In this context, I am interested in the research of new potential therapeutic targets and strategies for the treatment of neurodegenerative diseases, with focus on mitochondrial dynamics and endogenous antioxidant machinery. Particularly, as part of my post-doctoral project, I am assessing the putative neuroprotective role of glutathione S-transferase pi (GSTP), a downstream target of Nrf2, against oxidative damage in the brain.
Carvalho AN, Marques C, Guedes RC, Castro-Caldas M, Rodrigues E, van Horssen J, Gama MJ. S-Glutathionylation of Keap1: a new role for glutathione S-transferase pi in neuronal protection. FEBS Lett 2016: 590: 1455-66.
Carvalho AN, Firuzi O, Gama MJ, van Horssen J, Saso L. Oxidative stress and antioxidants in neurological diseases: is there still hope? Curr Drug Targets 2016; Apr 1 [Epub ahead of print].
Carvalho AN, Marques C, Rodrigues E, Henderson CJ, Wolf CR, Pereira P, Gama MJ. Ubiquitin-Proteasome System impairment and MPTP-induced Oxidative Stress in the brain of C57BL/6 wild-type and GSTP knockout mice. Mol Neurobiol 2013; 47: 662-72.
Castro-Caldas M*, Carvalho AN*, Rodrigues E, Henderson C, Wolf CR, Gama MJ. Glutathione S-Transferase pi mediates MPTP-induced c-Jun N terminal kinase activation in the nigrostriatal pathway. Mol Neurobiol 2012; 45: 466-77 (*joint first authors).
Castro-Caldas M*, Carvalho AN*, Rodrigues E, Henderson CJ, Wolf CR, Rodrigues CMP, Gama MJ. Tauroursodeoxycholic acid prevents MPTP-induced dopaminergic cell death in a mouse model of Parkinson’s disease. Mol Neurobiol 2012; 46: 475-86 (*joint first authors).