Andreia N. Carvalho
PhD (2012) in Pharmacy (Biochemistry), Universidade de Lisboa
Postdoctoral Fellow, VU University Medical Center, Amsterdam, The Netherlands
Post-Doctoral Fellow (FCT), iMed.ULisboa, Faculdade de Farmácia, Universidade de Lisboa
Faculdade de Farmácia, Universidade de Lisboa — Av. Prof. Gama Pinto, 1649-003 Lisboa, Portugal
My main research focus is on the molecular mechanisms underlying mitochondrial dysfunction, oxidative stress/endoplasmic reticulum stress and associated neuro-axonal damage leading to neurodegeneration. In this context, I am interested in the search of new potential therapeutic targets and strategies for the treatment of neurodegenerative diseases, with a focus on mitochondrial dynamics and endogenous antioxidant machinery. Particularly, I am assessing the neuroprotective role of GSTP and Nrf2-Keap1 pathway, against oxidative damage in the brain.
Carvalho AN*, Firuzi O, Gama MJ, van Horssen J, Saso L. Oxidative stress and antioxidants in neurological diseases: is there still hope? Curr Drug Targets 2017; 18: 705-18. *Corresponding author
Carvalho AN, Marques C, Guedes RC, Castro-Caldas M, Rodrigues E, van Horssen J, Gama MJ. S-Glutathionylation of Keap1: a new role for glutathione S-transferase pi in neuronal protection. FEBS Lett 2016; 590: 1455-66.
Carvalho AN, Marques C, Rodrigues E, Henderson CJ, Wolf CR, Pereira P, Gama MJ. Ubiquitin-Proteasome System impairment and MPTP-induced Oxidative Stress in the brain of C57BL/6 wild-type and GSTP knockout mice. Mol Neurobiol 2013; 47: 662-72.
Castro-Caldas M*, Carvalho AN*, Rodrigues E, Henderson C, Wolf CR, Gama MJ. Glutathione S-Transferase pi mediates MPTP-induced c-Jun N terminal kinase activation in the nigrostriatal pathway. Mol Neurobiol 2012; 45: 466-77. *Joint first authors
Castro-Caldas M*, Carvalho AN*, Rodrigues E, Henderson CJ, Wolf CR, Rodrigues CMP, Gama MJ. Tauroursodeoxycholic acid prevents MPTP-induced dopaminergic cell death in a mouse model of Parkinson’s disease. Mol Neurobiol 2012; 46: 475-86. *Joint first authors