Ana Sofia M. Ressurreição

PhD (2008) in Medicinal Chemistry (Université Paris-Sud) and Chemistry (Università degli Studi dell’Insubria)
FCT Investigator, Medicinal Chemistry

Faculdade de Farmácia, Universidade de Lisboa — Av. Prof. Gama Pinto, 1649-003 Lisboa, Portugal

T (+351) 217946400
F (+351) 217946470
Researcher ID M-6695-2013

Research Interests

My research interests include the design and synthesis of small molecule modulators of proteins identified as key therapeutic targets in infectious diseases and cancer. Particular emphasis has been given to the development of new chemical entities able to target malaria and Trypanosomes parasites. Another major interest is the development of suitable click chemical probes for live-cell imaging and drug-target protein profiling (chemoproteomics) of the most promising inhibitors.

Selected Publications

Rodrigues T, da Cruz FP, Lafuente-Monasterio MJ, Gonçalves D, Ressurreição AS, Sitoe, AR, Bronze MR, Gut J, Schneider G, Mota MM, Rosenthal PJ, Prudêncio M, Gamo FJ, Lopes F, Moreira R. Quinolin-4(1H)-imines are Potent Antiplasmodial Drugs Targeting the Liver Stage of Malaria. J. Med. Chem. 2013; 56: 4811-4815.

Ressurreição AS, Gonçalves D, Sitoe AR, Albuquerque IS, Gut J, Gois A, Gonçalves LM, Bronze MR, Hanscheid T, Biagini GA, Rosenthal PJ, Prudêncio M, O’Neill P, Mota MM, Lopes F, Moreira R. Structural Optimization of Quinolon-4(1H)-imines as Dual-Stage Antimalarials: Towards Increased Potency and Metabolic Stability. J. Med. Chem. 2013; 56: 7679-7690.

Hanson KK, Ressurreição AS, Buchholz K, Prudêncio M, Herman-Ornelas JD, Rebelo M, Beatty W L, Wirth DF, Hanscheid T, Moreira R, Marti M, Mota MM. Torins are potent antimalarials that block replenishment of Plasmodium liver stage parasitophorous vacuole membrane proteins. Proc. Natl. Acad. Sci. U. S. A. 2013; 110: E2838-E2847.

Dufau L, Ressurreição ASM, Fanelli R, Kihal N, Vidu A, Milcent T, Soulier J-L, Rodrigo J, Desyergne A, Leblanc K, Bernadat G, Crousse B, Reboud-Ravaux M, Ongeri S. Carbonylhydrazide-Based Molecular Tongs Inhibit Wild-Type and Mutated HIV-1 Protease Dimerization. J. Med. Chem. 2012; 55: 6762-6775.

Ressurreição ASM, Vidu A, Civera M, Belvisi L, Potenza D, Manzoni L, Ongeri S, Gennari C, Piarulli U. Cyclic RGD-Peptidomimetics Containing Bifunctional Diketopiperazine Scaffolds as New Potent Integrin Ligands. Chem. Eur. J. 2009; 15: 12184-12188.