Ana S. Ressurreição

PhD (2008) in Medicinal Chemistry (Université Paris-Sud) and Chemistry (Università degli Studi dell’Insubria)
FCT Investigator, Medicinal Chemistry

Faculdade de Farmácia, Universidade de Lisboa — Av. Prof. Gama Pinto, 1649-003 Lisboa, Portugal

T (+351) 217946400
F (+351) 217946470
Researcher ID M-6695-2013
Group Researcher ID B-4834-2014
Scopus Author ID 6503878873

Research Interests

My research interests include the design and synthesis of small molecule modulators of enzymes and proteins identified as key therapeutic targets in infectious diseases and cancer. Particular emphasis has been given do the development of new chemical entities able to target different protozoan parasites. Another major interest is the development of biocompatible click probes for live-cell imaging and drug-target protein profiling of the compounds developed. The final goal will be to develop suitable chemical tools to uncover the mechanism of action of a particular chemotype and identify and validate the corresponding drug target(s).

Selected Publications

Duarte AR, Enrico C, Ressurreição AS, Moreira R, Paulo A. Design of Modular G-quadruplex Ligand.  ChemMedChem 2018. Doi: https://doi.org/10.1002/cmdc.201700747.

Fanelli F*, Ressurreição AS, Dufau L, Soulier JL, Vidu A, Tonali N, Bernadat G, Reboud-Ravaux, M, Ongeri S*. Introduction of polar groups on the naphthalene scaffold of molecular tongs inhibiting wild-type and mutated HIV-1 protease dimerization. Med Chem Commun. 2014; 5: 719-727. (*authors with equal contribution)

Hanson KK, Ressurreição AS, Buchholz K, Prudêncio M, Herman-Ornelas JD, Rebelo M, Beatty W L, Wirth DF, Hanscheid T, Moreira R, Marti M, Mota MM. Torins are potent antimalarials that block replenishment of Plasmodium liver stage parasitophorous vacuole membrane proteins. Proc Natl Acad Sci USA 2013; 110: E2838-E2847.

Ressurreição AS, Gonçalves D, Sitoe AR, Albuquerque IS, Gut J, Gois A, Gonçalves LM, Bronze MR, Hanscheid T, Biagini GA, Rosenthal PJ, Prudêncio M, O’Neill P, Mota MM, Lopes F, Moreira R. Structural Optimization of Quinolon-4(1H)-imines as Dual-Stage Antimalarials: Towards Increased Potency and Metabolic Stability. J Med Chem 2013; 56: 7679-7690.

Rodrigues T, da Cruz FP, Lafuente-Monasterio MJ, Gonçalves D, Ressurreição AS, Sitoe, AR, Bronze MR, Gut J, Schneider G, Mota MM, Rosenthal PJ, Prudêncio M, Gamo FJ, Lopes F, Moreira R. Quinolin-4(1H)-imines are Potent Antiplasmodial Drugs Targeting the Liver Stage of Malaria. J Med Chem 2013; 56: 4811-4815.