Ana R. Vaz

PhD (2010) in Pharmacy (Molecular and Cellular Biology), Faculdade de Farmácia, Universidade de Lisboa
Invited Assistant Professor, Department of Biochemistry and Human Biology, FFULisboa

Faculdade de Farmácia, Universidade de Lisboa — Av. Prof. Gama Pinto, 1649-003 Lisboa, Portugal

T (+351) 217 946 400
F (+351) 217 946 491
Researcher ID M-5149-2013
Group Researcher ID B-5403-2014
Scopus Author ID 35851090700

Research Interests

Ana research focus on the mechanisms underlying glia response and interplay with neurons in neurodegenerative diseases, namely ALS and AD. She is involved in the isolation of microvesicles and exosomes from different models (microglia, astrocyte primary cultures, motor neuron, microglia cell lines and iPSCs-derived neurons and astrocytes), and in their characterization (NTA, protein/ gene/ microRNA profile). She is also interested in evaluating inflammatory mediators in monocultures, co-cultures and brain/ spinal cord from ALS mice model.

Selected Publications

Cunha C, Santos C, Gomes C, Fernandes A, Correia AM, Sebastião AM, Vaz AR, Brites D. Downregulated Glia Interplay and Increased miRNA-155 as Promising Markers to Track ALS at an Early Stage. Mol Neurobiol 2018; 55: 4207-4224.

Pinto S, Cunha C, Barbosa M, Vaz AR, Brites D. Exosomes from NSC-34 Cells Transfected with hSOD1-G93A Are Enriched in miR-124 and Drive Alterations in Microglia Phenotype. Front Neurosci 2017; 11: 273.

Caldeira C, Cunha C, Vaz AR, Falcão AS, Barateiro A, Seixas E, Fernandes A, Brites D. Key aging-associated alterations in primary microglia response to beta-amyloid stimulation. Front Aging Neurosci 2017; 9: 277.

Vaz AR, Cunha C, Gomes C, Schmucki N, Barbosa M, Brites D. Glycoursodeoxycholic acid reduces matrix metalloproteinase-9 and caspase-9 activation in a cellular model of superoxide dismutase-1 neurodegeneration. Mol Neurobiol 2015; 51: 864-77.

Vaz AR, Delgado-Esteban M, Brito MA, Bolaños JP, Brites D, Almeida A. Bilirubin selectively inhibits cytochrome c oxidase activity and induces apoptosis in immature cortical neurons: assessment of the protective effects of glycoursodeoxycholic acid. J Neurochem 2010; 112: 56-65.