Ana P. Marreilha dos Santos
PhD (1993) in Pharmacy (Toxicology), Universidade de Lisboa
Assistant Professor, Toxicological and Bromatological Sciences, Faculdade de Farmácia, Universidade de Lisboa
Faculdade de Farmácia, Universidade de Lisboa — Av. Prof. Gama Pinto, 1649-003 Lisboa, Portugal
The main goal of our research is the improvement of public health exploring and integrating investigation in mechanistic toxicology, biomarkers and risk assessment.
Herein the research is focused on the mode of action of several metals in order to identify targets and select endpoints of neurotoxicity to be used as predictive biomarkers of disease. Another goal of our research is the identification of early biomarkers of neurotoxicity to be used in the control and prevention of the risk of chronic low levels exposure to a metal mixture in human populations.
SantosD , Aschner M, Marreilha dos Santos AP. “Manganese and Neurodegeneration” Chapter 8, in Biometals in Neurodegenerative Diseases, Academic Press 2017. ISBN 978-0-12-804562-6
Andrade V, Mateus ML, Batoréu MC, Aschner M and Marreilha dos Santos AP. Changes in rat urinary porphyrin profiles predict the magnitude of the neurotoxic effects induced by a mixture of lead, arsenic and manganese. NeuroToxicology 2014; 45: 168–177.
Andrade V, Mateus ML, Batoréu MC, Aschner M and Marreilha dos Santos, AP. Urinary delta-ALA: A potential biomarker of exposure and neurotoxic effect in rats co-treated with a mixture of lead, arsenic and manganese. NeuroToxicology 2013; 11: 33-41.
Santos D, Batoréu MC, Tavares de Almeida I, Randall D, Mateus ML, Andrade V, Ramos R, Torres E, Aschner M and Marreilha dos Santos AP. Evaluation of neurobehavioral and neuroinﬂammatory end-points in the post-exposure period in rats sub-acutely exposed to manganese. Toxicology 2013; 314, 95 – 99.
Marreilha dos Santos AP, Lucas RL, Andrade V, Mateus ML, Milatovic D, Aschner M and Batoréu MC. Protective effects of ebselen and para-aminosalicylic acid (PAS) on manganese- induced neurotoxicity. Toxicol Appl Pharmacol 2012, 258: 394-402.