Ana Paula Marreilha dos Santos
PhD (1993) in Pharmacy (Toxicology), Universidade de Lisboa
Assistant Professor, Toxicology
Faculdade de Farmácia, Universidade de Lisboa — Av. Prof. Gama Pinto, 1649-003 Lisboa, Portugal
Mechanisms of toxicity and their modulation with protector agents have been studied using in vitro (blood brain barrier model-RBE4 cells) and in vivo assays. Lately, the research has been focused on the mechanism of toxicity of manganese (Mn) compounds, aiming the study and implementation of new early biomarkers to be applied in Clinical and Occupational Toxicology. The effects resulting from the exposure to a mixture of metals, and the selection of the adequate biomarkers to prevent its neurotoxicity, are also under study in a recent project.
Andrade V, Mateus ML, Batoréu MC, Aschner M, Marreilha dos Santos AP. Urinary delta-ALA: a potential biomarker of exposure and neurotoxic effect in rats co-treated with a mixture of lead, arsenic and manganese. NeuroToxicology 2013; Vol 38, 33-41.
Marreilha dos Santos AP, Lucas Rui L, Andrade Vanda, Mateus M, Luísa, Milatovic Dejan, Aschner Michael, Batoreu M Camila. Protective effects of ebselen (Ebs) and para-aminosalicylic acid (PAS) against manganese (Mn)-induced neurotoxicity. Toxicol Appl Pharmacol 2012; Vol 258 (3); 394-402.
Santos D, Milatovic D, Andrade V, Batoreu MC., Aschner M, Marreilha dos Santos AP. The inhibitory effect of manganese on acetylcholinesterase activity enhances oxidative stress and neuroinflammation in the rat brain. Toxicology 2012; 26; 292(2-3), 90-8.
Marreilha dos Santos AP, Lopes Santos M, Batoréu MC, Aschner M. Prolactin is a peripheral marker of manganese neurotoxicity. Brain Res 2011; 1382:282-90.
Marreilha dos Santos AP, Milatovic D, Au C, Yin Z, Batoreu MCC, Aschner M. Rat brain endothelial cells are a target of manganese toxicity. Brain Res 2010; Vol 1326: 152-161.