Ana Paula Francisco

PhD (2005) in Pharmacy (Pharmaceutical Chemistry), Universidade de Lisboa

Assistant Professor, Pharmaceutical Chemistry and Organic Chemistry

 

Faculdade de Farmácia, Universidade de Lisboa — Av. Prof. Gama Pinto, 1649-003 Lisboa, Portugal

T (+351) 217 946 400
F (+351) 217946470
Researcher ID M-4178-2013
Group Researcher ID B-4834-2014
Scopus Author ID 8441555200

Research Interests

Francisco research interests have included: the design and synthesis of drugs and prodrugs with anticancer activity, specially focused on the treatment of metastatic malignant melanoma; the development of novel chemical delivery systems with targeting properties and the molecular optimization of bioactive molecules obtained either from natural sources or from synthesis. More recently, she joined the team of Alexandra Paulo and have been involved in the synthesis of small molecules as G-quadruplexes ligands for the treatment of cancer.

Selected Publications

Brito H, Martins AC, Lavrado J, Mendes E, Francisco AP, Santos SA, Ohnmacht SA, Kim NS, Rodrigues CM, Moreira R, Neidle S, Borralho PM, Paulo A. Targeting KRAS Oncogene in Colon Cancer Cells with 7-Carboxylate Indolo[3,2-b]quinoline Tri-Alkylamine Derivatives. PLoS One 2015; 29:e0126891.

Monteiro AS, Almeida J, Cabral G, Severino P, Videira AP, Sousa A, Nunes R, Pereira JD, Francisco AP, Perry MJ, Mendes E. Synthesis and evaluation of N-acylamino acids derivatives of triazenes”. Activation by tyrosinase in human melanoma cell lines. Eur J Med Chem 2013; 70: 1-9.

Rijo P, Simões MF, Francisco AP, Rojas R, Gilman RH, Vaisberg AJ, Rodríguez B, Moiteiro C. Antimycobacterial metabolites from Plectranctus. Royleanone derivatives against Mycobacterium tuberculosis strains. Chem Biodivers 2010; 7: 922-932.

Perry MJ, Mendes E, Simplício AL, Coelho A., Soares RV, Iley J, Moreira R, Francisco AP. Dopamine and Tyramine-based derivatives of triazenes: activation by tyrosinase and implications for prodrug design. Eur J Med Chem 2009; 44:3228-3234.

 Carvalho E, Francisco APG, Iley J, Rosa E. Triazene Drug Metabolites. Part 17: Synthesis and Plasma Hydrolysis of Acyloxymethyl Carbamate Derivatives of Antitumour Triazenes. Bioorg Med Chem 2000; 8: 1719-1725.