Ana Paula Francisco
PhD (2005) in Pharmacy (Pharmaceutical Chemistry), Universidade de Lisboa
Assistant Professor, Pharmaceutical Chemistry and Organic Chemistry
Faculdade de Farmácia, Universidade de Lisboa — Av. Prof. Gama Pinto, 1649-003 Lisboa, Portugal
Francisco research interests are mainly in the design and synthesis of drugs and prodrugs with anticancer activity. Mainly research has been focused on the development of novel chemical delivery systems with targeting properties and the molecular optimization of bioactive molecules obtained either from natural sources or from synthesis. More recently, she joined the team of Alexandra Paulo and has been involved in the synthesis of small molecules as G-quadruplexes ligands for the treatment of cancer, and the development of chemical probes for cell-live bio-imaging.
Sousa A, Santos F, Gaspar MM, Calado S, Pereira JD, Mendes E, Francisco AP*, Perry MJ. The Selective Cytotoxicity of New Triazene Compounds to Human Melanoma Cells. Bioorg Med Chem 2017; 25: 3900-3910
Brito H, Martins AC, Lavrado J, Mendes E, Francisco AP, Santos SA, Ohnmacht SA, Kim NS, Rodrigues CM, Moreira R, Neidle S, Borralho PM, Paulo A. Targeting KRAS Oncogene in Colon Cancer Cells with 7-Carboxylate Indolo[3,2-b]quinoline Tri-Alkylamine Derivatives. PLoS One 2015; 29:e0126891.
Rijo P, Duarte A, Francisco AP, Semedo-Lemsaddak T, Simões MF. In vitro Antimicrobial Activity of Royleanone derivatives against Gram-Positive Bacterial Pathogens. Phytother Res 2014; 28: 76-81
Monteiro AS, Almeida J, Cabral G, Severino P, Videira AP, Sousa A, Nunes R, Pereira JD, Francisco AP, Perry MJ, Mendes E. Synthesis and evaluation of N-acylamino acids derivatives of triazenes. Activation by tyrosinase in human melanoma cell lines. Eur J Med Chem 2013; 70: 1-9.
Carvalho E, Francisco APG, Iley J, Rosa E. Triazene Drug Metabolites. Part 17: Synthesis and Plasma Hydrolysis of Acyloxymethyl Carbamate Derivatives of Antitumour Triazenes. Bioorg Med Chem 2000; 8: 1719-1725.