Ana Paula Francisco
PhD (2005) in Pharmacy (Pharmaceutical Chemistry), Universidade de Lisboa
Assistant Professor, Pharmaceutical Chemistry and Organic Chemistry
Faculdade de Farmácia, Universidade de Lisboa — Av. Prof. Gama Pinto, 1649-003 Lisboa, Portugal
Ana Francisco mainly research interests have been directed to the design and synthesis of triazenes derivatives with anticancer activity and the molecular optimization of bioactive molecules obtained either from natural sources or from synthesis. Lately, research has been dedicated to the development of dual action prodrugs and other hybrid compounds with targeting properties. Recently, she joined the team of Alexandra Paulo and has been involved in the optimization of indoloquinoline alkaloids and the synthesis of small molecules as G-quadruplexes ligands for the treatment of cancer and the development of chemical probes for live cell imaging.
Sousa A, Santos F, Gaspar MM, Calado S, Pereira JD, Mendes E, Francisco AP*, Perry MJ. The Selective Cytotoxicity of New Triazene Compounds to Human Melanoma Cells. Bioorg Med Chem 2017; 25: 3900-3910
Brito H, Martins AC, Lavrado J, Mendes E, Francisco AP, Santos SA, Ohnmacht SA, Kim NS, Rodrigues CM, Moreira R, Neidle S, Borralho PM, Paulo A. Targeting KRAS Oncogene in Colon Cancer Cells with 7-Carboxylate Indolo[3,2-b]quinoline Tri-Alkylamine Derivatives. PLoS One 2015; 29:e0126891.
Rijo P, Duarte A, Francisco AP, Semedo-Lemsaddak T, Simões MF. In vitro Antimicrobial Activity of Royleanone derivatives against Gram-Positive Bacterial Pathogens. Phytother Res 2014; 28: 76-81
Monteiro AS, Almeida J, Cabral G, Severino P, Videira AP, Sousa A, Nunes R, Pereira JD, Francisco AP, Perry MJ, Mendes E. Synthesis and evaluation of N-acylamino acids derivatives of triazenes. Activation by tyrosinase in human melanoma cell lines. Eur J Med Chem 2013; 70: 1-9.
Perry MJ, Mendes E, Simplício AL, Coelho A., Soares RV, Iley J, Moreira R, Francisco AP. Dopamine and Tyramine-based derivatives of triazenes: activation by tyrosinase and implications for prodrug design. Eur J Med Chem 2009; 44: 3228-3234.