PhD (2006) in Pharmacy (Pharmaceutical Chemistry), Universidade de Lisboa
Assistant Professor with Agregation, Toxicological and Bromatological Sciences, Faculdade de Farmácia, Universidade de Lisboa
Faculdade de Farmácia, Universidade de Lisboa — Av. Prof. Gama Pinto, 1649-003 Lisboa, Portugal
Bettencourt major research interests are in the improvement of the therapeutic effects of local drug-delivery-systems for application in biomaterials-associated-infections (dental and orthopaedic). Specifically, novel strategies to overcome implant-associated infections are being developed mainly by the production and complete characterization (mechanical, physical and biological) of innovative polymeric local-drug delivery devices with controlled release properties and high anti-biofilm activity against multi-resistant pathogens.
Martin V, Ribeiro IA, Alves MM, Gonçalves L, Claudio RA, Grenho L, Fernandes MH Gomes P, Santos CF, Bettencourt AF. Engineering a multifunctional 3D-printed PLA-collagen-minocycline-nanoHydroxyapatite scaffold with combined antimicrobial and osteogenic effects for bone regeneration. Mater Sci Eng C Mater BiolAppl. 2019; 101:15-26.
Woischnig AK, Gonçalves LM, Ferreira M, Kuehl R, Kikhney J, Moter A, Ribeiro IAC, Almeida AJ, Khanna N,Bettencourt AF. Acrylic microparticles increase daptomycin intracellular and in vivo anti-biofilm activity against Staphylococcus aureus. Int J Pharm. 2018; 550: 372-379.
Graça D, Louro H, Santos J, Dias K, Almeida AJ, Gonçalves L, Silva MJ, Bettencourt A. Toxicity screening of a novel poly(methylmethacrylate)-Eudragit nanocarrier on L929 fibroblasts. Toxicol Lett. 2017; 276:129-137.
Santos-Ferreira I, Bettencourt A, Gonçalves LM, Kasper S, Bétrisey B, Kikhney J, Moter A, Trampuz A, Almeida AJ. Activity of Daptomycin and vVancomycin-loaded poly-epsilon-caprolactone microparticles against mature staphylococcal biofilms. Int J Nanomedicine. 2015; 10:4351-66.
Matos A, Ribeiro I, Guedes R, Pinto R, Vaz M, Gonçalves L, Almeida AJ, Bettencourt A. Key-properties Outlook of a levofloxacin-loaded acrylic bone cement with improved antibiotic delivery. Int J Pharm. 2015; 85: 317-28.