Ana Francisca de Campos Simão Bettencourt

PhD (2006) in Pharmacy (Pharmaceutical Chemistry), Universidade de Lisboa
Assistant Professor, Toxicological and Bromatological Sciences

Faculdade de Farmácia, Universidade de Lisboa — Av. Prof. Gama Pinto, 1649-003 Lisboa, Portugal

T (+351) 217 946 400
F (+351) 217 946 470
Researcher ID M-4219-2013
Group Researcher ID B-4215-2014
Scopus Author ID 6603687672

Research Interests

Bettencourt major research interests are in the improvement of the therapeutic effects of local drug delivery systems for application in bone infections. Specifically, novel strategies to overcome implant-associated infections are being developed mainly by the production and full characterization of  innovative polymeric local-drug delivery devices with controlled release properties and high anti-biofilm activity against multi-resistant pathogens in prosthetic-associated infections.

Selected Publications

Bettencourt A, Almeida AJ. Poly(methyl methacrylate): Drug Delivery Applications. Mishra MK (ed.), in “Encyclopedia of Biomedical Polymers and Polymeric Biomaterials, CRC Press, Taylor and Francis, ISBN1-13: 9781439898796. 2015.

Santos-Ferreira I, Bettencourt A, Gonçalves LM, Kasper S, Bétrisey B, Kikhney J, Moter A, Trampuz A, Almeida AJ. Activity of Daptomycin and vVancomycin-loaded poly-epsilon-caprolactone microparticles against mature staphylococcal biofilms. Int J Nanomedicine. 2015 (accepted).

Matos A, Ribeiro I, Guedes R, Pinto R, Vaz M, Gonçalves L, Almeida AJ, Bettencourt A. Key- properties Outlook of a levofloxacin-loaded acrylic bone cement with improved antibiotic delivery. Int J Pharm. 2015; 15;485(1-2):317-28.

Santos-Ferreira I, Bettencourt A, Betrisey B, Gonçalves LM, Trampuz A, Almeida AJ. Improvement of the Antibacterial Activity of Daptomycin-loaded Polymeric Microparticles by Eudragit RL 100: an Assessment by Isothermal Microcalorimetry. Int. J. Pharm. 2015; 485, 171–182.

Matos A, Gonçalves LM, Rijo P, Vaz M, Almeida AJ, Bettencourt A. A novel modified acrylic bone cement matrix. A step forward on antibiotic delivery against multiresistant bacteria responsible for prosthetic joint infections. Mat Sci and Engineering: C. 2014; 38 (1), 218–226.