Alexandra Paulo

PhD (1998) in Pharmacy, University of London
Professor Habilitation Title (2014), Pharmacy (Pharmaceutical and Medicinal Chemistry), Universidade de Lisboa
Assistant Professor, Pharmaceutical and Medicinal Chemistry

Faculdade de Farmácia, Universidade de Lisboa — Av. Prof. Gama Pinto, 1649-003 Lisboa, Portugal

T (+351) 217 946 473
F (+351) 217 946 470
Researcher ID M-6683-2013
Group Researcher ID B-4834-2014
Scopus Author ID 7003821508

Research Interests

Paulo’s research has been focus on the discovery of innovative chemical tools and drug lead small molecules for malaria and cancer therapies. A. Paulo leads a team of PhD researchers and post-graduation students with expertise in the design and synthesis of indoloquinolines and others related chemical scaffolds, as well in the evaluation of their capacities to modulate malaria parasite vital pathways or to target nucleic acids G-quadruplex structures and repress oncogene expression in cancer cells.

Selected Publications

Paulo A, Castillo CC, Neidle S. Targeting Promoter Quadruplex Nucleic Acids for Cancer Therapy. In: Chackalamannil S, Rotella DP and Ward SE (eds.) Comprehensive Medicinal Chemistry III, 2017, vol. 5, pp. 308–340. Oxford: Elsevier. ISBN: 9780128032008.

Lavrado J, Brito H, Borralho PM, Ohnmacht SA, Kim NS, Leitão C, Pisco S, Gunaratnam M, Rodrigues CMP, Moreira R, Neidle S, Paulo A*. KRAS oncogene repression in colon cancer cell lines by G-quadruplex binding indolo[3,2-c]quinolines. Sc Rep 2015; 5: 9696.

Brito H, Martins AC, Lavrado J, Mendes E, Francisco AP, Santos SA, Ohnmacht SA, Kim NS, Rodrigues CMP, Moreira R, Neidle S, Borralho PM*, Paulo A*. Targeting KRAS oncogene in colon cancer cells with 7-carboxylate indolo[3,2-b]quinoline tri-alkylamine derivatives. PlosOne 2015; 10: e0126891.

Santos SA, Lukens AK, Coelho L, Nogueira F, Wirth DF, Mazitschek R, Moreira R, Paulo A*. Exploring the 3-piperidin-4-yl-1H-indole scaffold as a novel antimalarial chemotype. Eur J Med Chem 2015; 102: 320-33.

Paulo A*, Figueiras M, Machado M, Charneira C, Lavrado J, Santos SA, Lopes D, Gut J, Rosenthal PJ, Nogueira F, Moreira R. Bis-alkylamine indolo(3,2-b)quinolines as hemozoin ligands: implications for antimalarial cytostatic and cytocidal activities. J Med Chem 2014; 57: 3295-313.