Alexandra Paulo

PhD (1998) in Pharmacy (Pharmacognosy), University of London
Assistant Professor, Pharmaceutical and Medicinal Chemistry

Faculdade de Farmácia, Universidade de Lisboa — Av. Prof. Gama Pinto, 1649-003 Lisboa, Portugal

T (+351) 217 946 437
F (+351) 217 946 470
Researcher ID M-6683-2013
Group Researcher ID B-4834-2014
Scopus Author ID 7003821508

Research Interests

Paulo’s work has been focus on the discovery of novel chemical scaffolds, either from natural sources or by rational design of new molecules, for the treatment of malaria, diabetes and cancer. She has been actively involved in the study of Portuguese medicinal plants, as well as in the design, synthesis and biological evaluation of indoloquinoline analogues targeting malaria parasite heme detoxification pathway or DNA G-quadruplex structures in cancer cells.

Selected Publications

Lavrado J,Borralho PM, Ohnmacht SA, Castro RE, Rodrigues CMP, Moreira R, dos Santos DJVA, Neidle S, Paulo A. Synthesis, G-quadruplexstabilisation, docking studies and effect on cancer cells of indolo[3,2-b]quinolines with one, two, or three basic side chains. ChemMedChem 2013; 8: 1648-61.

Dias T, Liu B, Jones P, Houghton PJ, Mota-Filipe H, Paulo A. Cytoprotective effect of Coreopsis tinctoria extracts and flavonoids on tBHP and cytokine-induced cell injury in pancreatic MIN6 cells. J Ethnopharmacol 2012; 139: 485-92.

Lavrado J, Cabal GG, Prudêncio M, Mota MM, Gut J, Rosenthal PJ, Díaz C, Guedes RC, Santos DJVA, Bichenkova E, Douglas KT, Moreira R, Paulo A. Incorporation of basic side chains into cryptolepine scaffold: structure-antimalarial activity relationships and mechanistic studies. J Med Chem 2011; 54: 734-50.

Lavrado J, Reska AP, Moreira R, Neidle S, Paulo A. C-11 diaminocryptolepine derivatives NSC748392, NSC748393 and NSC748394: anticancer profile and G-quadruplex stabilization. Bioorg Med Chem Lett 2010; 20: 7042-5.

Paulo A, Gomes ET, Steele J, Warhurst DC, Houghton PJ.Antiplasmodial activity of Cryptolepis sanguinolenta alkaloids from leaves and roots. Planta Med 2000; 66: 30-4.