Adelaide Fernandes

PharmD (2002) Faculty of Pharmacy, Universidade de Lisboa and PhD (2006) in Pharmacy (Biochemistry), Universidade de Lisboa
Assistant Professor, Department of Biochemistry and Human Biology, FFULisboa

Faculdade de Farmácia, Universidade de Lisboa — Av. Prof. Gama Pinto, 1649-003 Lisboa, Portugal

T (+351) 217 946 400
F (+351) 217 946 491
Researcher ID A-4787-2011
Group Researcher ID B-5403-2014
Scopus Author ID 8896201000

Research Interests

Adelaide research focus on the role of neuroinflammation in neurodevelopment and neurodegenerative disorders. Adelaide addresses the relevance of microglia/astrocyte-neuron interplay in Alzheimer’s disease, exploring the role of microRNAs and vesicle-mediated cellular communication in relevant disease models as patient-derived iPSCs. Adelaide is also interested in inflammatory demyelinating disorders, as Multiple Sclerosis, addressing how glia and immune response may modulate oligodendrogenesis and so disease pathogenesis and psycopathology.

Selected Publications

Barateiro A, Afonso V, Santos G, Cerqueira JJ, Brites D, van Horssen J, Fernandes A. S100B as a biomarker and therapeutic target in multiple sclerosis. Mol Neurobiol 2016; 53: 3976-91.

Cardoso FL, Herz J, Fernandes A, Rocha J, Sepodes B, Brito MA, McGavern DB, Brites D. Systemic inflammation in early neonatal mice induces transient and lasting neurodegenerative effects. J Neuroinflamation 2015; 12: 82.

Caldeira C, Oliveira AF, Cunha C, Vaz AR, Falcão AS, Fernandes A, Brites D. Microglia change from a reactive to an age-like phenotype with the time in culture. Front Cell Neurosci 2014; 8: 152.

Barateiro A, Miron VE, Santos SD, Relvas JB, Fernandes A, Ffrench-Constant C, Brites D. Unconjugated bilirubin restricts oligodendrocyte differentiation and axonal myelination. Mol Neurobiol 2013; 47: 632-644.

Fernandes A, Barateiro A, Falcão AS, Silva SL, Vaz AR, Brito MA, Silva RFM, Brites D. Astrocyte reactivity to unconjugated bilirubin requires TNF-alpha and IL-1beta receptor signaling pathways. Glia 2011; 59: 14-25.